Covid-19: MIS-C syndrome in children

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Since the coronavirus outbreak, researchers around the world have reported the onset of post-Covid inflammatory syndrome in children. Called MIS-C syndrome, it would result in a lot of heart damage. What are the symptoms and who are most affected? What is the link between MIS-C and Covid-19? Let’s do a check in.

What is MIS-C syndrome?

It was Dr. Brodin, the Swedish pediatrician at Karolinska University Hospital in Stockholm, who discovered the syndrome that scientists have called MIS-C. Multisystem inflammatory syndrome in children (MIS-C) is a condition characterized by inflammation of the walls of blood vessels. Also called pediatric multisystem inflammatory syndrome (PMIS), the syndrome has many features common to those of Kawasaki disease.

During the coronavirus epidemic last April, doctors warned that these inflammatory symptoms were developing in children. MIS-C is said to develop about 4 to 6 weeks after infection. It is usually manifested by the onset of high fever, dysfunction of high inflammatory marker organs (such as the heart, lungs, kidneys, brain, skin, eyes). Since the alert issued by the UK’s National Health Service at the end of April, MIS-C has already affected more than a thousand children and young adults worldwide. There are nearly 200 in France.

What is the link with Covid-19?

If the link between Covid-19 and MIS-C questions the entire scientific community, it is because most young patients with the disease present, according to studies, antibodies against SARS-CoV-2 (the virus responsible for Covid-19 pandemic) or a positive serology vis-à-vis the new coronavirus.

Researchers at the University of Texas, San Antonio conducted a study (published in the journal EClinicalMedicine) and attempted to prove that MIS-C is closely related to Covid-19. To do this, they deciphered nearly 40 studies on the subject listing 663 children with MIS-C. According to the results, the syndrome could affect children who do not present a priori, any symptoms and who are otherwise in good health. Dr Alvaro Moreira of the University of Texas says, “Children don’t need to have the classic respiratory tract symptoms of Covid-19 to develop MIS-C, which is worrying.”

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